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06/2026

ONA THERAPEUTICS acquired by COLUMBUS VENTURE PARTNERS & MERIEUX EQUITY PARTNERS

SPAIN Life Sciences / Pharma & Biotech / R&D Biotech REV 1m EUR - 100m EUR

Context

The closing of this oversubscribed 86.6 million dollar Series B financing represents a structural capitalization event designed to transition Ona Therapeutics into a clinical-stage oncology platform and fund operations through its primary clinical data readouts. This institutional funding round replaces early-stage venture capital with a deep-pocketed, clinically-focused investment syndicate capable of supporting the high cash-burn rate associated with executing Phase I/II clinical trials for lead program ONA-255 in breast cancer patients. The capital injection also provides the financial runway required to advance second asset ONA-389 into regulatory first-in-human studies for colorectal cancer, thereby transforming a single-product risk profile into a diversified, multi-asset clinical pipeline. Post-transaction governance priorities involve the active integration of incoming board nominees from Columbus and Mérieux with Ona’s established clinical advisory board to oversee global clinical strategy, optimize regulatory pathways with international health authorities, and clear preclinical development milestones for broader solid tumor indications, positioning the unencumbered worldwide rights of the asset for premium monetization.

ONA THERAPEUTICS, which reported an EBITDA margin of LOGIN in 2026, is valued in this transaction at an EV/EBITDA multiple of LOGIN, a level to compare with the average currently observed in the Healthcare & Pharma sector (14.8x).

Note that this data is based on contribution from our growing community, composed of M&A and Private Equity professionals, and has been verified by our team to ensure its accuracy.

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Target

Ona Therapeutics is a late-preclinical stage biopharmaceutical company pioneering the development of first-in-class antibody-drug conjugates engineered to overcome tumor resistance and metastatic progression in refractory solid tumors. The company deploys a proprietary, patient-driven target discovery platform that isolates novel tumor-specific antigens and internalizing epitopes, enabling the selective delivery of potent cytotoxic payloads directly into drug-resistant cancer cells while preserving a wide therapeutic index. The asset pipeline is led by ONA-255, a high-affinity ADC targeting advanced breast cancer indications scheduled for imminent clinical trial initiation, followed by ONA-389, a separate preclinical candidate being advanced toward first-in-human studies for colorectal cancer. Operating under an asset-centric corporate model, the entity maintains full worldwide commercial intellectual property rights across its entire pipeline, utilizing specialized contract research organizations to execute its development workflows. The financial profile of the business is characterized by pre-revenue, capital-intensive research operations where economic enterprise value is explicitly driven by regulatory milestone translation, data-readout inflection points, and the validation of human safety and efficacy profiles within highly competitive oncology indications.

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Historical Financials (EUR)

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2026
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REFERENCES

Note: This page provides detailed data on a private equity M&A transaction. Detailed and exact financial metrics for the acquisition of ONA THERAPEUTICS by COLUMBUS VENTURE PARTNERS / MERIEUX EQUITY PARTNERS are reserved for mynth community members. Register for free to unlock full data.

Authors: verified mynth contributor (mynth data is contributed by M&A / PE professionals and systematically cross-verified with private deal documents and official press releases).

Target: ona therapeutics

Acquirer: columbus venture partners / merieux equity partners